Asymmetric synthesis of 3-substituted pyrrolidones via α-alkylation of a chiral non-racemic γ-lactam

被引：29
|
作者：
Baussanne, I [1 ]
Travers, C [1 ]
Royer, J [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 05期
关键词：
D O I：
10.1016/S0957-4166(98)00024-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
3-Alkyl pyrrolidones 9 were synthesized in good yield and high diastereoselectivity by oc-alkylation of the new chiral non-racemic lactam 8 derived from (R)-(-)-phenylglycinol. After debenzylation and introduction of an electron-withdrawing group, 3-methylpyrrolidone 10 is easily hydrolyzed in a basic medium to produce gamma-aminobutyric acid (GABA) analogue 13. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：797 / 804
页数：8
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