Clinically Meaningful Improvements in Early Morning and Late Afternoon/Evening Functional Impairment in Children with ADHD Treated with Delayed-Release and Extended-Release Methylphenidate

被引：8

作者：

Wilens, Timothy E. ^{[1
,2
,3
]}

Faraone, Stephen, V ^{[5
]}

Hammerness, Paul G. ^{[4
,6
]}

Pliszka, Steven R. ^{[7
]}

Uchida, Cassandra L. ^{[8
]}

DeSousa, Norberto J. ^{[9
]}

Sallee, Floyd R. ^{[11
]}

Incledon, Bev ^{[10
]}

Newcorn, Jeffrey H. ^{[12
]}

机构：

[1] Massachusetts Gen Hosp, Child & Adolescent Psychiat, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Addict Med, Boston, MA 02114 USA

[3] Harvard Med Sch, Psychiat, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Psychiat, Psychiat, Boston, MA 02115 USA

[5] SUNY Upstate Med Univ, Syracuse, NY 13210 USA

[6] Boston Childrens Hosp, Outpatient Psychiat Serv, Boston, MA USA

[7] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[8] Highland Therapeut Inc, Toronto, ON, Canada

[9] Ironshore Pharmaceut & Dev Inc, Clin Operat, Camana Bay, Grand Cayman, Cayman Islands

[10] Ironshore Pharmaceut & Dev Inc, Res & Dev, Camana Bay, Grand Cayman, Cayman Islands

[11] Ironshore Pharmaceut Inc, Durham, NC USA

[12] Mt Sinai Med Ctr, Psychiat & Pediat, New York, NY 10029 USA

来源：

JOURNAL OF ATTENTION DISORDERS | 2022年 / 26卷 / 05期

关键词：

ADHD; methylphenidate; functional impairment; BSFQ; PREMB-R; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; UNITED-STATES; ADOLESCENTS;

D O I：

10.1177/10870547211020073

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: The Before School Functioning Questionnaire and Parent Rating of Evening and Morning Behavior-Revised assess early morning (BSFQ, PREMB-R AM subscale) and late afternoon/evening (PREMB-R PM subscale) functional impairment in children with ADHD. Clinically meaningful improvements were identified and applied to a trial of delayed-release and extended-release methylphenidate (DR/ER-MPH) in children with ADHD (NCT02520388) to determine if the statistically-determined improvements in functional impairment were also clinically meaningful. Method: Clinically meaningful improvements in BSFQ/PREMB-R were established post hoc by receiver operating characteristics curves, using anchors of Clinical Global Impression-Improvement (CGI-I) = 1 and CGI-I <= 2. Percentages of participants achieving these thresholds were calculated. Results: Thresholds for CGI-I = 1/CGI-I <= 2, respectively, were 27/20 (BSFQ), 5/3 (PREMB-R AM), and 9/5 (PREMB-R PM)-point decreases. More children achieved clinically meaningful improvements with DR/ER-MPH versus placebo (all p < .05). Conclusion: DR/ER-MPH increased proportions of children achieving clinically meaningful improvements in BSFQ and PREMB-R.

引用

页码：696 / 705

页数：10

共 21 条

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