Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

被引：39
|
作者：
Vecchione, Matthew K. [1 ]
Li, Le [1 ]
Seidel, Daniel [1 ]
机构：
[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 25期
关键词：
AMINO ACID-DERIVATIVES; QUATERNARY AMMONIUM-SALTS; ASYMMETRIC-SYNTHESIS; CINCHONA ALKALOIDS; NONADJACENT STEREOCENTERS; CONJUGATE ADDITION; EFFICIENT APPROACH; CYCLIC-PEPTIDES; BOND DONORS; SCHIFF-BASE;
D O I：
10.1039/c0cc00556h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A readily available bifunctional thiourea catalyst promotes aldol additions of alpha-isothiocyanato imides to alpha-ketoesters under mild reaction conditions to form beta-hydroxy-alpha-amino acid derivatives with high levels of enantioselectivity.
引用
收藏
页码：4604 / 4606
页数：3
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