Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

被引：89
|
作者：
Hiebl, Verena [1 ]
Ladurner, Angela [1 ]
Latkolik, Simone [1 ]
Dirsch, Verena M. [1 ]
机构：
[1] Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria
来源：
BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 06期
关键词：
Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; LIVER-X-RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; ALISOL B 23-ACETATE; FAMILIAL COMBINED HYPERLIPIDEMIA; 7-ALPHA-HYDROXYLASE GENE CYP7A1; REVERSE CHOLESTEROL TRANSPORT; BINDING CASSETTE TRANSPORTER; UNSATURATED FATTY-ACIDS; HOPS HUMULUS-LUPULUS; 9-CIS RETINOIC ACID;
D O I：
10.1016/j.biotechadv.2018.03.003
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets. This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.
引用
收藏
页码：1657 / 1698
页数：42
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  • [1] Regulation of cholesterol metabolism by the nuclear receptors RXR, LXR, and FXR
    Sucov, HM
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    Debitus, C.
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