Why will it never be known if convalescent plasma is effective for COVID-19

被引：13

作者：

Rojas, Manuel ^{[1
]}

Anaya, Juan-Manuel ^{[1
,2
]}

机构：

[1] Univ Rosario, Ctr Autoimmune Dis Res CREA, Sch Med & Hlth Sci, Carrera 26-63-B-51, Bogota 110010, Colombia

[2] Clin Occidente, Bogota, Colombia

来源：

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY | 2020年 / 3卷

关键词：

Coronavirus; COVID-19; SARS-Cov-2; Convalescent plasma; Clinical trials; Randomized;

D O I：

10.1016/j.jtauto.2020.100069

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP disclose a high methodological variability in inclusion criteria, outcomes, appropriate selection of donors, dosage, concentration of neutralizing antibodies and times of transfusion. Therefore, at this time there is insufficient evidence to recommend for or against the use of CP as a treatment for COVID-19.

引用

页数：5

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