Recent Advances in Asymmetric Catalytic Methods for the Formation of Acyclic α,α-Disubstituted α-Amino Acids

被引：156

作者：

Metz, Alison E. ^{[1
]}

Kozlowski, Marisa C. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 01期

关键词：

HIGHLY ENANTIOSELECTIVE SYNTHESIS; PHASE-TRANSFER CATALYSTS; SUBSTITUTED NITROACETATES; 4+2 CYCLOADDITION; MICHAEL ADDITION; ALDOL REACTION; ALKYLATION; AMINATION; 1,4-ADDITION; CONSTRUCTION;

D O I：

10.1021/jo502408z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Because of their greater stability and unique conformational properties, unnatural amino acids are highly valued by pharmaceutical, biological, and organic chemists. This synopsis surveys the various catalytic methods used to access enantioenriched, acyclic a,a-disubstituted a-amino acids with a focus on the processes developed since 2007, when the last major reviews in this area were published.

引用

页码：1 / 7

页数：7

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