Molecular Mechanisms of Cardioprotective Actions of Tanshinones

被引：3
|
作者：
Jin, Hyou-Ju [1 ,2 ]
Li, Chun-Guang [1 ]
机构：
[1] Univ Western Sydney, Natl Inst Complementary Med, Penrith, NSW 2751, Australia
[2] RMIT Univ, Sch Hlth Sci, Div Chinese Med, Bundoora, Vic 3083, Australia
来源：
JOURNAL OF CHEMISTRY | 2016年 / 2016卷
关键词：
MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; SALVIA-MILTIORRHIZA BUNGE; NITRIC-OXIDE PRODUCTION; OXIDATIVE STRESS; CARDIAC FIBROBLASTS; IIA SULFONATE; HYDROGEN-PEROXIDE; MICROCIRCULATORY DISTURBANCE; APOE(-/-) MICE;
D O I：
10.1155/2016/9150108
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tanshinones are lipophilic compounds derived from Salvia miltiorrhiza (Danshen) that has been widely used to treat coronary heart diseases in China. The cardioprotective actions of tanshinones have been extensively studied in various models of myocardial infarction, cardiac ischemia reperfusion injury, cardiac hypertrophy, atherosclerosis, hypoxia, and cardiomyopathy. This review outlines the recent development in understanding the molecular mechanisms and signaling pathways involved in the cardioprotective actions of tanshinones, in particular on mitochondrial apoptosis, calcium, nitric oxide, ROS, TNF-alpha, PKC, PI3K/Akt, IKK/NF-kappa B, and TGF-beta 1/Smad mechanisms, which highlights the potential of these compounds as therapeutic agents for treating cardiovascular diseases.
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页数：14
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