Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol

被引：16
|
作者：
Kang, Hoe-Jong [1 ]
Kim, Jin-Hyun [1 ]
机构：
[1] Kongju Natl Univ, Dept Chem Engn, Cheonan 31080, South Korea
来源：
KOREAN JOURNAL OF CHEMICAL ENGINEERING | 2019年 / 36卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Amorphous Paclitaxel; Residual Solvent; Removal; Pretreatment with Alcohol; Drying; CELL-CULTURES; MECHANISM; KINETICS; THERMODYNAMICS; SOLUBILITY; ADSORPTION; ISOTHERM; SOLVENTS; SYSTEM;
D O I：
10.1007/s11814-019-0413-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A drying method that can effectively remove residual solvents from chloroform-induced amorphous paclitaxel was developed. Simple rotary evaporation with alcohol (methanol or ethanol) pretreatment was sufficient to remove residual chloroform and alcohol concentrations below the ICH limits (60 ppm for chloroform, 3,000 ppm for methanol, and 5,000 ppm for ethanol). In addition, SEM analysis and ultrasonic treatment showed that residual solvent removal is related to the porous structure of the sample due to the high vapor pressure of the chloroform-alcohol mixture and the hydrogen bonding between chloroform and alcohol.
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页码：1965 / 1970
页数：6
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