Interrelation of the content of transferrin, erythrocytes with the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation

The relationship between the content of transferrin and erythrocytes and the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation have been studied. It was found that in 49.21% of the examined individuals the content of transferrin increases against the background of a decrease in the level of the number of cells with a membrane receptor for transferrin (CD71 +), which reflects the known competing relationships of the receptor, the level of its shedding and substrate (transport). An increase in transferrin content is associated with an increase in the concentration of circulating IgG immune complexes in 44.21% of cases. With an increase in the concentration of transferrin in the blood in 27.95%, the content of platelets decreases and in 24.08% - the concentration of hemoglobin, mainly in men with increasing age. In 8.06% of the examined individuals, an increase in the level of transferrin is interrelated with an increase in the concentration of reagins. In 5.12% of cases, an increase in the transferrin content is associated with the activation of cell-mediated cytotoxicity, which is mainly supported by the pro-inflammatory cytokine IL-6. The relationship between the increase in transport protein and IL-10 concentration has not been established.