Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop

被引：88

作者：

Goldberg, Ira J. ^{[1
]}

Reue, Karen ^{[2
]}

Abumrad, Nada A. ^{[3
]}

Bickel, Perry E. ^{[4
]}

Cohen, Sarah ^{[5
]}

Fisher, Edward A. ^{[1
]}

Galis, Zorina S. ^{[6
]}

Granneman, James G. ^{[7
]}

Lewandowski, E. Douglas ^{[8
]}

Murphy, Robert ^{[9
]}

Olive, Michelle ^{[6
]}

Schaffer, Jean E. ^{[3
]}

Schwartz-Longacre, Lisa ^{[6
]}

Shulman, Gerald I. ^{[10
]}

Walther, Tobias C. ^{[11
]}

Chen, Jue ^{[6
]}

机构：

[1] NYU, New York, NY USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

[3] Washington Univ, St Louis, MO USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA

[5] Univ N Carolina, Chapel Hill, NC 27515 USA

[6] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA

[7] Wayne State Univ, Detroit, MI USA

[8] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA

[9] Univ Colorado, Denver, CO 80202 USA

[10] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA

[11] Harvard Univ, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CIRCULATION | 2018年 / 138卷 / 03期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; heart failure; metabolic syndrome; obesity; triglycerides; SMOOTH-MUSCLE-CELLS; FATTY-ACID UPTAKE; INSULIN-RESISTANCE; PERILIPIN; 5; PPAR-ALPHA; CHOLESTEROL ACCUMULATION; CARDIAC STEATOSIS; OXIDATIVE STRESS; PHYSICAL STATE; CD36; PROTEIN;

D O I：

10.1161/CIRCULATIONAHA.118.033704

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.

引用

页码：305 / 315

页数：11

共 50 条

[1] Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop
Ahluwalia, Amrita
Gladwin, Mark
Coleman, Gary D.
Hord, Norman
Howard, George
Kim-Shapiro, Daniel B.
Lajous, Martin
Larsen, Filip J.
Lefer, David J.
McClure, Leslie A.
Nolan, Bernard T.
Pluta, Ryszard
Schechter, Alan
Wang, Chia-Yih
Ward, Mary H.
Harman, Jane L.
[J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (07):
[2] The Role of the Lung Microbiome in Health and Disease A National Heart, Lung, and Blood Institute Workshop Report
Huang, Yvonne J.
Charlson, Emily S.
Collman, Ronald G.
Colombini-Hatch, Sandra
Martinez, Fernando D.
Senior, Robert M.
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (12) : 1382 - 1387
[3] Getting from Genes to Function in Lung Disease A National Heart, Lung, and Blood Institute Workshop Report
Ober, Carole
Butte, Atul J.
Elias, Jack A.
Lusis, A. Jake
Gan, Weiniu
Banks-Schlegel, Susan
Schwartz, David
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (06) : 732 - 737
[4] Report of the National Heart, Lung, and Blood Institute Workshop on Lipoprotein(a) and cardiovascular disease: Recent advances and future directions
Marcovina, SM
Koschinsky, ML
Albers, JJ
Skarlatos, S
[J]. CLINICAL CHEMISTRY, 2003, 49 (11) : 1785 - 1796
[5] Outcomes Research in Cardiovascular Imaging: Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute
Douglas, Pamela S.
Taylor, Allen
Bild, Diane
Bonow, Robert
Greenland, Philip
Lauer, Michael
Peacock, Frank
Udelson, James
[J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2009, 22 (07) : 766 - 773
[6] Outcomes Research in Cardiovascular Imaging Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute
Douglas, Pamela S.
Taylor, Allen
Bild, Diane
Bonow, Robert
Greenland, Philip
Lauer, Michael
Peacock, Frank
Udelson, James
[J]. JACC-CARDIOVASCULAR IMAGING, 2009, 2 (07) : 897 - 907
[7] Cell transplantation as future therapy for cardiovascular disease? A workshop of the National Heart, Lung, and Blood Institute
Reinlib, L
Field, L
[J]. CIRCULATION, 2000, 101 (18) : E182 - E187
[8] Future Directions for Cardiovascular Disease Comparative Effectiveness Research Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute
Hlatky, Mark A.
Douglas, Pamela S.
Cook, Nakela L.
Wells, Barbara
Benjamin, Emelia J.
Dickersin, Kay
Goff, David C.
Hirsch, Alan T.
Hylek, Elaine M.
Peterson, Eric D.
Roger, Veronique L.
Selby, Joseph V.
Udelson, James E.
Lauer, Michael S.
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (07) : 569 - 580
[9] Prevention of Atrial Fibrillation Report From a National Heart, Lung, and Blood Institute Workshop
Benjamin, Emelia J.
Chen, Peng-Sheng
Bild, Diane E.
Mascette, Alice M.
Albert, Christine M.
Alonso, Alvaro
Calkins, Hugh
Connolly, Stuart J.
Curtis, Anne B.
Darbar, Dawood
Ellinor, Patrick T.
Go, Alan S.
Goldschlager, Nora F.
Heckbert, Susan R.
Jalife, Jose
Kerr, Charles R.
Levy, Daniel
Lloyd-Jones, Donald M.
Massie, Barry M.
Nattel, Stanley
Olgin, Jeffrey E.
Packer, Douglas L.
Po, Sunny S.
Tsang, Teresa S. M.
Van Wagoner, David R.
Waldo, Albert L.
Wyse, D. George
[J]. CIRCULATION, 2009, 119 (04) : 606 - 618
[10] Meeting Report for the 2017 National Institutes of Health National Heart, Lung, and Blood Institute Progenitor Cell Biology Consortium Cardiovascular Bioengineering Workshop and Symposium
Zhu, Wuqiang
Zhang, Jianyi
[J]. CIRCULATION RESEARCH, 2017, 120 (11) : 1709 - 1712

← 1 2 3 4 5 →