Application of nanotechnology for the production of masculinized Tilapia, Oreochromis niloticus (Linnaeus, 1758)

Nanoparticles (NPs) are believed to be the best drug delivery system. The present research work has been designed to develop (poly lactic-co-glycolic acid) (PLGA) loaded fadrozole nanoparticles for producing all male population of tilapia (Oreochromis niloticus Linnaeus, 1758). For both 350 ppm and 500 ppm groups, 100% males were produced, when observed at 30 days experiment. The percentage of males was highest in the 500 ppm of fadrozole-loaded PLGA fed groups with values of 92.35 +/- 0.86 and 97.76 +/- 1.12% at 10 and 15 days experiment respectively., The lowest male percentage was found in the 50 ppm group, indicating proportionate effect of the NP. It was also observed that the male percentage of the naked fadrozole at 500 ppm and fadrozole PLGA NPs at 50 ppm were 88.96% and 89.31%, respectively. These findings indicate that fadrozole in nano forms can reduce 90% of prescribed dose of fadrozole for masculinization of commercial fish like tilapia.