Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

被引：43

作者：

Amiri, Houshang ^{[1
]}

de Sitter, Alexandra ^{[1
]}

Bendfeldt, Kerstin ^{[2
]}

Battaglini, Marco ^{[3
]}

Wheeler-Kingshott, Claudia A. M. Gandini ^{[4
]}

Calabrese, Massimiliano ^{[5
]}

Geurts, Jeroen J. G. ^{[6
]}

Rocca, Maria A. ^{[7
]}

Sastre-Garriga, Jaume ^{[8
]}

Enzinger, Christian ^{[9
,10
]}

de Stefano, Nicola ^{[3
]}

Filippi, Massimo ^{[7
]}

Rovira, Alex ^{[11
]}

Barkhof, Frederik ^{[1
,12
,13
]}

Vrenken, Hugo ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[2] Med Image Anal Ctr MIAC AG Basel, Basel, Switzerland

[3] Univ Siena, Dept Med Surg & Neurosci, Siena, Italy

[4] UCL Inst Neurol, NMR Res Unit, Dept Neuroinflammat, Queen Sq MS Ctr, London, England

[5] Univ Verona, Multiple Sclerosis Ctr, Dept Neurosci Biomedicine & Movements, Neurol Sect, Verona, Italy

[6] Vrije Univ Amsterdam, Med Ctr, Anat & Neurosci, Amsterdam Neurosci, Amsterdam, Netherlands

[7] Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Milan, Italy

[8] Univ Autonoma Barcelona, Serv Neurol Neuroimmunol, Multiple Sclerosis Ctr Catalonia Cemcat, Hosp Univ Vall dHebron, Barcelona, Spain

[9] Med Univ Graz, Dept Neurol, Graz, Austria

[10] Med Univ Graz, Div Neuroradiol Vasc & Intervent Radiol, Dept Radiol, Graz, Austria

[11] Univ Autonoma Barcelona, Unitat Ressonancia Magnet, Serv Radiol, Hosp Univ Vall dHebron, Barcelona, Spain

[12] UCL, Inst Neurol, London, England

[13] UCL, Inst Healthcare Engn, London, England

来源：

NEUROIMAGE-CLINICAL | 2018年 / 19卷

关键词：

Multiple sclerosis; Brain atrophy; Grey matter; Magnetic resonance imaging; PROGRESSIVE MULTIPLE-SCLEROSIS; VOXEL-BASED MORPHOMETRY; DEEP GRAY-MATTER; CORTICAL THICKNESS MEASUREMENTS; SURFACE-BASED ANALYSIS; ABNORMAL WHITE-MATTER; REGIONAL GREY; IN-VIVO; HIPPOCAMPAL ATROPHY; T1-WEIGHTED IMAGES;

D O I：

10.1016/j.nicl.2018.04.023

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.

引用

页码：466 / 475

页数：10

共 50 条

[1] The contribution of white matter lesions to whole brain and deep grey matter atrophy in patients with MS
Mahajan, Kedar
Nakamura, Kunio
Feng, Jenny
Macaron, Gabrielle
Moss, Brandon
McGinley, Marisa
Li, Hong
Jones, Stephen
Lowe, Mark
Boissy, Adrienne
Conway, Devon
Fox, Robert
Rae-Grant, Alexander
Rensel, Mary
Willis, Mary
Bermel, Robert
Cohen, Jeffrey
Ontaneda, Daniel
[J]. NEUROLOGY, 2019, 92 (15)
[2] Brain MRI atrophy quantification in MS From methods to clinical application
Rocca, Maria A.
Battaglini, Marco
Benedict, Ralph H. B.
De Stefano, Nicola
Geurts, Jeroen J. G.
Henry, Roland G.
Horsfield, Mark A.
Jenkinson, Mark
Pagani, Elisabetta
Filippi, Massimo
[J]. NEUROLOGY, 2017, 88 (04) : 403 - 413
[3] Evaluation of automated techniques for the quantification of grey matter atrophy in patients with multiple sclerosis
Derakhshan, Mishkin
Caramanos, Zografos
Giacomini, Paul S.
Narayanan, Sridar
Maranzano, Josefina
Francis, Simon J.
Arnold, Douglas L.
Collins, D. Louis
[J]. NEUROIMAGE, 2010, 52 (04) : 1261 - 1267
[4] Grey matter hypoperfusion and subsequent brain atrophy in MS: a longitudinal MRI study with pseudo-continuous arterial spin labeling
Freeman, L.
Lincoln, J. A.
Narayana, P. A.
Wolinsky, J. S.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 224 - 225
[5] Sources of variability in brain atrophy measurements in individual MS patients
Tsang, A.
Wager, C.
Jennings, D.
Bermel, R.
Jones, S. E.
Izbudak, I.
Lui, Y. W.
Krupp, L.
Mowry, E. M.
de Moor, C.
Rudick, R.
Williams, J. R.
Fisher, E.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 265 - 266
[6] Patterns of Grey Matter Atrophy in Patients with MS: A Multivariate Analysis Using Source-based Morphometry
Rocca, Maria A.
Valsasina, Paola
Meani, Alessandro
Gobbi, Claudio
Zecca, Chiara
Rovira, Alex
Montalban, Xavier
Kearney, Hugh
Ciccarelli, Olga
Matthews, Lucy
Palace, Jacqueline
Gallo, Antonio
Bisecco, Alvino
Lukas, Carsten
Bellenberg, Barbara
Barkhof, Frederik
Vrenken, Hugo
Preziosa, Paolo
Filippi, Massimo
[J]. NEUROLOGY, 2020, 94 (15)
[7] Patterns of grey matter atrophy in patients with MS: a multivariate analysis using source-based morphometry
Valsasina, P.
Meani, A.
Gobbi, C.
Zecca, C.
Rovira, A.
Montalban, X.
Kearney, H.
Ciccarelli, O.
Matthews, L.
Palace, J.
Gallo, A.
Bisecco, A.
Lukas, C.
Bellenberg, B.
Barkhof, F.
Vrenken, H.
Preziosa, P.
Rocca, M. A.
Filippi, M.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2019, 25 : 231 - 233
[8] Patterns of grey matter atrophy in patients with MS: a multivariate analysis using source-based morphometry
Rocca, M. A.
Valsasina, P.
Meani, A.
Gobbi, C.
Zecca, C.
Rovira, A.
Montalban, X.
Kearney, H.
Ciccarelli, O.
Matthews, L.
Palace, J. A.
Gallo, A.
Bisecco, A.
Lukas, C.
Bellenberg, B.
Barkhof, F.
Vrenken, H.
Preziosa, P.
Filippi, M.
[J]. EUROPEAN JOURNAL OF NEUROLOGY, 2020, 27 : 28 - 28
[9] Use of MRI to Measure Whole Brain Atrophy in MS Patients
Mazgaj, P.
Drzazga, Z.
Karpiel, I.
Giec-Lorenz, A.
Krzystanek, E.
[J]. ACTA PHYSICA POLONICA A, 2018, 133 (03) : 725 - 727
[10] Accelerated rate of grey matter brain atrophy after menopause in a longitudinal cohort of women with MS
Nylander, Alyssa
Silverman, Hannah
Akula, Amit
Bostrom, Alan
Lazar, Ann
Gomez, Refujia Cuquita
Santaniello, Adam
Harms, Meagan
Cooper, Tiffany
Renschen, Adam
Hauser, Stephen
Henry, Roland
Cree, Bruce
Bove, Riley
[J]. MULTIPLE SCLEROSIS JOURNAL, 2023, 29 : 133 - 133

← 1 2 3 4 5 →