The lipid peroxidation in breast cancer patients

被引：18
|
作者：
Kedzierska, Magdalena [1 ]
Olas, Beata [1 ]
Wachowicz, Barbara [1 ]
Jeziorski, Arkadiusz [2 ]
Piekarski, Janusz [2 ]
机构：
[1] Univ Lodz, Dept Gen Biochem, PL-90237 Lodz, Poland
[2] Med Univ Lodz, Dept Surg Oncol, Lodz, Poland
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2010年 / 29卷 / 02期
关键词：
Breast cancer; Oxidative stress; Isoprostanes; TBARS;
D O I：
10.4149/gpb_2010_02_208
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of our study was to estimate oxidative stress (by using different biomarkers of lipid peroxidation - isoprostanes and thiobarbituric acid reactive substances (TBARS)) in patients with invasive breast cancer, patients with benign breast diseases and in a control group. We observed a statistically increased level of TBARS in plasma and isoprostanes in urine of patients with invasive breast cancer in comparison with a control group. The concentration of tested biomarkers in plasma or urine from patients with invasive breast cancer was also higher than in patients with benign breast diseases. Moreover, the levels of tested markers in patients with benign breast diseases and in a control group did not differ. Considering the data presented in this study, we suggest that free radicals induce peroxidation of unsaturated fatty acid in patients with breast cancer.
引用
收藏
页码：208 / 210
页数：3
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