Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations

被引：4

作者：

Wright, Erik ^{[1
]}

Hafner, John W. ^{[2
]}

Podolej, Gregory ^{[2
]}

Feinstein, Douglas L. ^{[3
]}

van Breemen, Richard ^{[4
]}

Rubinstein, Israel ^{[5
]}

Aks, Steven ^{[6
]}

Wahl, Michael ^{[7
]}

机构：

[1] Univ Illinois, Coll Med Peoria, OSF St Francis Med Ctr, Dept Emergency Med, 530 NE Glen Oak Ave, Peoria, IL 61637 USA

[2] Univ Illinois, Coll Med Peoria, Dept Emergency Med, Peoria, IL 61637 USA

[3] Univ Illinois, Jesse Brown VA Med Ctr, Dept Anesthesiol, Chicago, IL USA

[4] Oregon State Univ, Dept Pharmaceut Sci, Linus Pauling Inst, Corvallis, OR 97331 USA

[5] Univ Illinois, Jesse Brown VA Med Ctr, Div Pulm Crit Care Sleep & Allergy Med, Chicago, IL USA

[6] Rush Univ, Dept Emergency Med, Chicago, IL 60612 USA

[7] John H Stroger Hosp Cook Cty, Dept Emergency Med, Chicago, IL USA

来源：

WESTERN JOURNAL OF EMERGENCY MEDICINE | 2021年 / 22卷 / 04期

关键词：

BRODIFACOUM; DRUGS; OUTBREAK;

D O I：

10.5811/westjem.2021.2.46317

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Introduction: Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred secondary to contaminated synthetic cannabinoids. Methods: We conducted a retrospective cohort study consisting of 38 patients to describe the initial emergency department (ED) presentation, diagnosis, and treatment. Results: Through serum testing we found that three long-acting anticoagulant rodenticides (LAAR) were detected in patients who had inhaled these tainted products: brodifacoum, difenacoum, and bromodialone. Discussion: This study encompasses the largest ED presentation of LAAR poisoning via the inhalational route known to date. Conclusion: The emergency physician should be aware of the potential for tainted coingestants as the cause of undifferentiated coagulopathy.

引用

页码：1014 / 1019

页数：6

共 3 条

[1] Severe Vitamin K-Dependent Coagulopathy Associated With Contaminated Synthetic Cannabinoid Exposure in Illinois
Hafner, J. W., Jr.
Wright, E.
Devgun, J.
Rasin, A.
Aks, S.
Wahl, M.
Chuko, J.
Wang, H.
[J]. ANNALS OF EMERGENCY MEDICINE, 2018, 72 (04) : S153 - S153
[2] Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids
Feinstein, Douglas L.
Nosal, Daniel G.
Ramanathan, Swetha
Zhou, Jifang
Chen, Luying
Hershow, Ronald C.
van Breemen, Richard B.
Wright, Erik
Hafner, John W.
Rubinstein, Israel
[J]. CLINICAL TOXICOLOGY, 2020, 58 (07) : 716 - 724
[3] Safe Treatment Duration with Oral Vitamin K1in Patients Poisoned with Inhaled Synthetic Cannabinoids Contaminated with Brodifacoum, a Long-Acting Anticoagulant Rodenticide
Rubinstein, I.
Feinstein, D.
Van Breemen, R.
Hafner, J.
Nosal, D.
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)

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