Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents

被引：220
|
作者：
Altmann, Karl-Heinz [1 ]
Gertsch, Juerg [1 ]
机构：
[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland
来源：
NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 02期
关键词：
RING CLOSING METATHESIS; EPOTHILONE-B ANALOG; III BETA-TUBULIN; BIOSYNTHETIC GENE-CLUSTER; MEDIATED ALDOL REACTIONS; HUMAN TUMOR XENOGRAFTS; LARGE-SCALE SYNTHESIS; I CLINICAL-TRIAL; BIOLOGICAL EVALUATION; MARINE SPONGE;
D O I：
10.1039/b515619j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.
引用
收藏
页码：327 / 357
页数：31
相关论文
共 50 条
  • [1] Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents (vol 24, pg 327, 2007)
    Altmann, Karl-Heinz
    Gertsch, Juerg
    NATURAL PRODUCT REPORTS, 2012, 29 (12) : 1481 - 1481
  • [2] Microtubule-stabilizing agents: a growing class of important anticancer drugs
    Altmann, KH
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (04) : 424 - 431
  • [3] Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
    Prota, Andrea E.
    Bargsten, Katja
    Zurwerra, Didier
    Field, Jessica J.
    Fernando Diaz, Jose
    Altmann, Karl-Heinz
    Steinmetz, Michel O.
    SCIENCE, 2013, 339 (6119) : 587 - 590
  • [4] Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents
    Chen, Xiaoyan
    Winstead, Angela
    Yu, Hongtao
    Peng, Jiangnan
    CANCERS, 2021, 13 (04) : 1 - 19
  • [5] New-generation taxoids and hybrids of microtubule-stabilizing anticancer agents.
    Ojima, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U131 - U131
  • [6] Microtubule-stabilizing natural products as promising cancer therapeutics
    Gallagher, Brian M., Jr.
    CURRENT MEDICINAL CHEMISTRY, 2007, 14 (28) : 2959 - 2967
  • [7] Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents
    Paterson, Ian
    Gardner, Nicola M.
    Naylor, Guy J.
    PURE AND APPLIED CHEMISTRY, 2009, 81 (02) : 169 - 180
  • [8] Microtubule-stabilizing agents: New drug discovery and cancer therapy
    Zhao, Ying
    Mu, Xin
    Du, Guanhua
    PHARMACOLOGY & THERAPEUTICS, 2016, 162 : 134 - 143
  • [9] Anticancer agents from unique natural products sources
    Ireland, CM
    Aalbersberg, W
    Andersen, RJ
    Ayral-Kaloustian, S
    Berlinck, RGS
    Bernan, V
    Carter, G
    Churchill, ACL
    Clardy, J
    Concepcion, GP
    De Silva, ED
    Discafani, C
    Fojo, T
    Frost, P
    Gibson, D
    Greenberger, LM
    Greenstein, M
    Harper, MK
    Mallon, R
    Loganzo, F
    Nunes, M
    Poruchynsky, MS
    Zask, A
    PHARMACEUTICAL BIOLOGY, 2003, 41 : 15 - 38
  • [10] Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity
    Rayan, Anwar
    Raiyn, Jamal
    Falah, Mizied
    PLOS ONE, 2017, 12 (11):
12345