Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor

被引：30
|
作者：
Pandey, V [1 ]
Bolsover, SR [1 ]
机构：
[1] UCL, Dept Physiol, London WC1E 6BT, England
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 274卷 / 01期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
rat; AIDS; HIV-associated dementia; HAD; CXCR4; chemokine; hippocampal culture; cortical culture;
D O I：
10.1006/bbrc.2000.3113
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Primary rat hippocampal neurones show pronounced elevations of intracellular calcium within minutes of exposure to the HIV coat protein gp120. Culture of hippocampal neurones with gp120 causes significant neurotoxicity. We find that the peptide VSLSYRCPCRFF, a competitive inhibitor of the CXCR4 chemokine receptor, markedly inhibits toxicity and eliminates the acute calcium elevation. CXCR4 receptors are thought to signal to the Gi/Go family of trimeric GTP binding proteins. Pretreatment of hippocampal neurones with pertussis toxin to inactivate Gi/Go proteins markedly reduced gp120 neurotoxicity. These results indicate that both short and long term effects of gp120 are the result of activation of the CXCR4 receptor. (C) 2000 Academic Press.
引用
收藏
页码：212 / 215
页数：4
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