Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

被引：48
|
作者：
Vismara, Elena [1 ]
Bongio, Chiara [1 ]
Coletti, Alessia [1 ]
Edelman, Ravit [2 ]
Serafini, Andrea [1 ]
Mauri, Michele [3 ]
Simonutti, Roberto [3 ]
Bertini, Sabrina [4 ]
Urso, Elena [4 ]
Assaraf, Yehuda G. [5 ]
Livney, Yoav D. [2 ]
机构：
[1] Politecn Milan, Dept Chem Mat & Chem Engn G Natta, I-20131 Milan, Italy
[2] Technion Israel Inst Technol, Biotechnol & Food Engn Dept, IL-3200000 Haifa, Israel
[3] Univ Milano Bicocca, Dept Mat Sci, I-20125 Milan, Italy
[4] Ist Sci Chim & Biochim G Ronzoni, I-20133 Milan, Italy
[5] Technion Israel Inst Technol, Biol Dept, IL-3200000 Haifa, Israel
来源：
MOLECULES | 2017年 / 22卷 / 07期
关键词：
super paramagnetic iron oxide nanoparticles (SPION); hyaluronic acid (HA); bovine serum albumin (BSA); Fe3O4 center dot DA-BSA/HA; paclitaxel (PTX); magnetic resonance imaging (MRI); MAGNETIC-RESONANCE; NANOCRYSTALS; STABILITY; MOLECULES; EFFICACY; BARRIERS; SYSTEM; AGENT;
D O I：
10.3390/molecules22071030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4 center dot DA-BSA/HA in water. Fe3O4 center dot DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4 center dot DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.
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页数：25
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