Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment

被引：7

作者：

Dygai, A. M. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Udut, E. V. ^{[1
]}

Zyuz'kov, G. N. ^{[1
]}

Simanina, E. V. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Trofimova, E. S. ^{[1
]}

Burmina, Ya. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, ED Goldberg Res Inst Pharmacol, Siberian Div, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 158卷 / 03期

关键词：

NF-kappa B; protein kinase p38; adenylatecyclase; myelosuppression; erythropoietin; HEMATOPOIESIS; MYELOSUPPRESSION; MECHANISMS;

D O I：

10.1007/s10517-015-2747-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment.

引用

页码：304 / 307

页数：4

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[1] Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment
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V. V. Zhdanov
L. A. Miroshnichenko
E. V. Udut
G. N. Zyuz’kov
E. V. Simanina
A. V. Chaikovskii
L. A. Stavrova
E. S. Trofimova
Ya. V. Burmina
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