In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

被引：0

作者：

van Loon, Welmoed ^{[1
]}

Oliveira, Rafael ^{[1
]}

Bergmann, Clara ^{[1
]}

Habarugira, Felix ^{[2
]}

Ndoli, Jules ^{[2
]}

Sendegeya, Augustin ^{[2
,3
]}

Bayingana, Claude ^{[4
]}

Mockenhaupt, Frank P. ^{[1
]}

机构：

[1] Charite, Berlin, Germany

[2] Univ Teaching Hosp Butare, Butare, Rwanda

[3] King Faisal Hosp, Kigali, Rwanda

[4] Univ Rwanda, Kigali, Rwanda

来源：

EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 04期

关键词：

COMBINATION THERAPY; MALARIA;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance. We document artemisinin resistance in P. falciparum patient isolates from Rwanda carrying K13 R561H, A675V, and C469F mutations.

引用

页码：852 / 855

页数：4

共 50 条

[1] Escalating Plasmodium falciparum K13 marker prevalence indicative of artemisinin resistance in southern Rwanda
van Loon, Welmoed
Schallenberg, Emma
Igiraneza, Clement
Habarugira, Felix
Mbarushimana, Djibril
Nshimiyimana, Fabian
Ngarambe, Christian
Ntihumbya, Jean Baptiste
Ndoli, Jules Minega
Mockenhaupt, Frank P.
Odom John, Audrey
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2024, 68 (01)
[2] Artemisinin resistance in Plasmodium falciparum
Lun, Zhao-Rong
Ferreira, Pedro E.
Fu, Lin-Chun
[J]. LANCET INFECTIOUS DISEASES, 2014, 14 (06): : 450 - 451
[3] In vitro phenotype of reduced susceptibility to artemisinin in Plasmodium falciparum isolates from western Cambodia
Witkowski, B.
Sokunmalis, K.
Kim, S.
Pheaktra, C.
Sopheakvatey, K.
Kloeung, N.
Khim, N.
Duong, S.
Leang, R.
Ringwald, P.
Dondorp, A. M.
Tripura, R.
Berry, A.
Benoit-Vical, F.
Barale, J. -C.
Mercereau-Puijalon, O.
Menard, D.
[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2012, 16 : E178 - E178
[4] Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
Owoloye, Afolabi
Olufemi, Michael
Idowu, Emmanuel T.
Oyebola, Kolapo M.
[J]. MALARIA JOURNAL, 2021, 20 (01)
[5] Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
Afolabi Owoloye
Michael Olufemi
Emmanuel T. Idowu
Kolapo M. Oyebola
[J]. Malaria Journal, 20
[6] Artemisinin Resistance-Associated K13 Polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010-2015
Tacoli, Costanza
Gai, Prabhanjan P.
Bayingana, Claude
Sift, Kevin
Geus, Dominik
Ndoli, Jules
Sendegeya, Augustin
Gahutu, Jean Bosco
Mockenhaupt, Frank P.
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2016, 95 (05): : 1090 - 1093
[7] In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon
Held, Jana
Soomro, Shahid A.
Kremsner, Peter G.
Jansen, F. Herwig
Mordmueller, Benjamin
[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (05) : 485 - 488
[8] In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials
Wongsrichanalai, C
Dung, NT
Trung, TN
Wimonwattrawatee, T
Sookto, P
Heppner, DG
Kawamoto, F
[J]. ACTA TROPICA, 1997, 63 (2-3) : 151 - 158
[9] Artemisinin resistance surveillance in African Plasmodium falciparum isolates from imported malaria cases to Italy
L'Episcopia, Mariangela
Bartoli, Tommaso Ascoli
Corpolongo, Angela
Mariano, Andrea
D'Abramo, Alessandra
Vulcano, Antonella
Paglia, Maria G.
Perrotti, Edvige
Menegon, Michela
Nicastri, Emanuele
Severini, Carlo
[J]. JOURNAL OF TRAVEL MEDICINE, 2021, 28 (05)
[10] Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda
Zeile, Irene
Gahutu, Jean-Bosco
Shyirambere, Cyprien
Steininger, Christian
Musemakweri, Andre
Sebahungu, Fidele
Karema, Corine
Harms, Gundel
Eggelte, Teunis A.
Mockenhaupt, Frank P.
[J]. ACTA TROPICA, 2012, 121 (01) : 50 - 54

← 1 2 3 4 5 →