Precision medicine approach to genetic cardiomyopathy

被引：0

作者：

Filonenko, K. ^{[1
]}

Katus, H. A. ^{[1
,2
]}

Meder, B. ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Inst Cardiomyopathies Heidelberg, Neuenheimer Feld 669, D-69120 Heidelberg, Germany

[2] DZHK, German Ctr Cardiovasc Res, Heidelberg, Germany

来源：

HERZ | 2017年 / 42卷 / 05期

关键词：

Mutations; Clustered regularly interspaced short palindromic repeats; Arrhythmia; Risk assessment; Gene repair; Sudden cardiac death; Genetic testing; Genome-wide association study; RIGHT-VENTRICULAR CARDIOMYOPATHY; IDIOPATHIC RESTRICTIVE CARDIOMYOPATHY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENOME-WIDE ASSOCIATION; RYANODINE RECEPTOR GENE; SUDDEN CARDIAC DEATH; HEAVY-CHAIN GENE; DILATED CARDIOMYOPATHY; HEART-FAILURE; INHERITED CARDIOMYOPATHIES;

D O I：

10.1007/s00059-017-4592-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Precision medicine aims to achieve improved survival by strategies that recognize the genetic and phenotypic individuality of patients and stratify treatment accordingly. Genetic cardiomyopathies represent an ideal disease group to fully embark on this concept: they are in total frequent diseases with a marked morbidity and mortality and there is ample knowledge about their predisposing genetic factors and associated functional mechanisms. The current review highlights the genetic etiology and gives examples of the diverse treatment strategies that are envisaged in the future.

引用

页码：468 / 475

页数：8

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