Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

被引：60
|
作者：
Xiao, Nan [1 ]
Quynh-Thu Le [2 ]
机构：
[1] Univ Pacific, Arthur A Dugoni Sch Dent, Dept Biomed Sci, San Francisco, CA USA
[2] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2016年 / 64卷 / 02期
关键词：
Neurotrophic factor; Tissue regeneration; NERVE GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; LONG-TERM POTENTIATION; BDNF MESSENGER-RNA; MICE LACKING NT4; SPINAL-CORD; IN-VITRO; FUNCTIONAL RECOVERY; FACTOR GENE; INTRAPUTAMINAL INFUSION;
D O I：
10.1007/s00005-015-0376-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.
引用
收藏
页码：89 / 99
页数：11
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