Verbal learning differences in chronic mild traumatic brain injury

被引:69
|
作者
Geary, Elizabeth K. [1 ,2 ]
Kraus, Marilyn F. [1 ,3 ,4 ]
Pliskin, Neil H. [1 ,3 ,4 ]
Little, Deborah M. [1 ,2 ,4 ,5 ,6 ,7 ]
机构
[1] Univ Illinois, Coll Med, Dept Neurol, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Med, Ctr Stroke Res, Chicago, IL 60612 USA
[3] Univ Illinois, Coll Med, Dept Psychiat, Chicago, IL 60612 USA
[4] Univ Illinois, Coll Med, Ctr Cognit Med, Chicago, IL 60612 USA
[5] Univ Illinois, Coll Med, Dept Anat, Chicago, IL 60612 USA
[6] Univ Illinois, Coll Med, Dept Ophthalmol, Chicago, IL 60612 USA
[7] Univ Illinois, Coll Med, Dept Psychol, Chicago, IL 60612 USA
关键词
Concussion; Diffusion tensor imaging; Single trial learning; POST-CONCUSSION SYMPTOMS; DIFFUSION-TENSOR; WHITE-MATTER; NEUROPSYCHOLOGICAL ASSESSMENT; COGNITIVE IMPAIRMENT; HEAD-INJURY; DEFICITS; MEMORY; DYSFUNCTION; STRESS;
D O I
10.1017/S135561771000010X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Following mild traumatic brain injury (TBI), a percentage of individuals report chronic memory and attention difficulties. Traditional neuropsychological assessments often fail to find evidence for such complaints. We hypothesized that mild TB! patients may, in fact, experience subtle cognitive deficits that reflect diminished initial acquisition that can be explained by changes in cerebral white matter microstructure. In the data presented here, a sample of nonlitigating and gainfully employed mild TBI patients demonstrated statistically significant differences from age and education matched control participants in performance on the first trial of a verbal learning task. Performance on this trial was associated with reduced fractional anisotropy in the uncinate fasciculus and the superior longitudinal fasciculus providing an anatomical correlate for the cognitive findings. Mild TBI patients were not impaired relative to control participants on total learning or memory composite variables. Performance on the first learning trial was not related to any psychological variables including mood. We concluded that patients with mild TBI demonstrate diminished verbal learning that is not often interpreted in standard neuropsychological assessment. (ENS, 2010, 16, 506-516.)
引用
收藏
页码:506 / 516
页数:11
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