Metal-free sulfonylative annulations of alkyl diiodides with sulfur dioxide: synthesis of cyclic aliphatic sulfones

被引：19

作者：

Jia, Xiuwen

Huang, Chunxi

Zhang, Xuemei ^{[1
]}

Lian, Zhong ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Dermatol,State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 19期

基金：

中国国家自然科学基金;

关键词：

INSERTION; GENERATION; POTENT; AMINOSULFONYLATION; CHEMISTRY; DISCOVERY; ROUTE; ACIDS;

D O I：

10.1039/d1qo00804h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward protocol for cyclic aliphatic sulfones is effectively established via sulfonylative annulations of alkyl diiodides and gaseous sulfur dioxide. In this transformation, SOgen serves as a safe, bench-stable and convenient SO2-surrogate. Five- to nine-membered cyclic aliphatic sulfones were smoothly afforded in an efficient manner. This protocol features moderate to high yields, good functional group compatibility and mild reaction conditions.

引用

页码：5310 / 5315

页数：6

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