The Role of Platelets in Diabetic Kidney Disease

被引:10
|
作者
Rustiasari, Ukhti Jamil [1 ,2 ,3 ]
Roelofs, Joris J. [1 ,2 ]
机构
[1] Univ Amsterdam, Amsterdam UMC, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Amsterdam Cardiovasc Sci, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Islam Indonesia, Fac Med, Dept Anat Pathol, Yogyakarta 55584, Indonesia
关键词
diabetes; diabetic kidney disease; diabetic nephropathy; platelets; platelet activation; biomarker; antiplatelet; SOLUBLE CD40 LIGAND; DRUG DILAZEP DIHYDROCHLORIDE; PLASMA BETA-THROMBOGLOBULIN; GLOMERULAR MESANGIAL CELL; FIBROBLAST-GROWTH-FACTOR; CHRONIC-RENAL-FAILURE; BERAPROST SODIUM; ACTIVATING-FACTOR; P-SELECTIN; ADHESION MOLECULES;
D O I
10.3390/ijms23158270
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.
引用
收藏
页数:35
相关论文
共 50 条
  • [1] Role of Platelets in Chronic Kidney Disease
    Jain, Nishank
    Corken, Adam L.
    Kumar, Amudha
    Davis, Clayton L.
    Ware, Jerry
    Arthur, John M.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (07): : 1551 - 1558
  • [2] Role of Zinc in Diabetic Kidney Disease
    Gembillo, Guido
    Visconti, Luca
    Giuffrida, Alfio Edoardo
    Labbozzetta, Vincenzo
    Peritore, Luigi
    Lipari, Antonella
    Calabrese, Vincenzo
    Piccoli, Giorgina Barbara
    Torreggiani, Massimo
    Siligato, Rossella
    Santoro, Domenico
    [J]. NUTRIENTS, 2022, 14 (07)
  • [3] The Role of Mitochondria in Diabetic Kidney Disease
    Stein Hallan
    Kumar Sharma
    [J]. Current Diabetes Reports, 2016, 16
  • [4] The Role of Mitochondria in Diabetic Kidney Disease
    Hallan, Stein
    Sharma, Kumar
    [J]. CURRENT DIABETES REPORTS, 2016, 16 (07)
  • [5] The role of inflammation in diabetic kidney disease
    Jung, Su Woong
    Moon, Ju-Young
    [J]. KOREAN JOURNAL OF INTERNAL MEDICINE, 2021, 36 (04): : 753 - 766
  • [6] What is the role of decorin in diabetic kidney disease?
    Mogyorósi, A
    Ziyadeh, FN
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (05) : 1078 - 1081
  • [7] Diabetic Kidney Disease: Is There a Role for Glycemic Variability?
    Savitha Subramanian
    Irl B. Hirsch
    [J]. Current Diabetes Reports, 2018, 18
  • [8] Role of Immune Cells in Diabetic Kidney Disease
    Yang, Xiaoqian
    Mou, Shan
    [J]. CURRENT GENE THERAPY, 2017, 17 (06) : 424 - 433
  • [9] Diabetic Kidney Disease: Is There a Role for Glycemic Variability?
    Subramanian, Savitha
    Hirsch, Irl B.
    [J]. CURRENT DIABETES REPORTS, 2018, 18 (03)
  • [10] Role for β-blockers in the management of diabetic kidney disease
    Bakris, GL
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (09) : 7S - 12S