Calcium and Heart Failure: How Did We Get Here and Where Are We Going?

被引：10

作者：

Siri-Angkul, Natthaphat ^{[1
,2
,3
]}

Dadfar, Behzad ^{[4
]}

Jaleel, Riya ^{[5
]}

Naushad, Jazna ^{[6
]}

Parambathazhath, Jaseela ^{[7
]}

Doye, Angelia ^{[8
]}

Xie, Lai-Hua ^{[1
]}

Gwathmey, Judith ^{[1
,9
]}

机构：

[1] Rutgers State Univ, Dept Cell Biol & Mol Med, New Jersey Med Sch, Newark, NJ 07103 USA

[2] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai 50200, Thailand

[4] Mazandaran Univ Med Sci, Sch Med, Dept Gen Med, Sari 1471655836, Iran

[5] Zhengzhou Univ, Sch Int Educ, Zhengzhou 450001, Peoples R China

[6] Weill Cornell Med Qatar, POB 24144, Doha, Qatar

[7] Proc Dynam Labs, Al Khor 679576, Qatar

[8] Gwathmey Inc, Cambridge, MA 02138 USA

[9] Boston Univ, Dept Med, Sch Med, Boston, MA 02118 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 14期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

heart failure; excitation-contraction coupling; myocardial contractility; myofilament; sarcoplasmic reticulum Ca2+ ATPase; sarcoplasmic reticulum; inotrope; beta blocker; calcium transient; hypoxia; FORCE-FREQUENCY-RELATIONSHIP; PRESSURE-OVERLOAD HYPERTROPHY; MAMMALIAN WORKING MYOCARDIUM; POTENTIAL CANONICAL CHANNELS; GUANYLATE-CYCLASE STIMULATOR; INTRACELLULAR CALCIUM; SARCOPLASMIC-RETICULUM; DILATED CARDIOMYOPATHY; ANIMAL-MODEL; GENE-THERAPY;

D O I：

10.3390/ijms22147392

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.

引用

页数：22

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