Syk in airway epithelial cells participates in β1 integrin signaling:: Role in nitric oxide production

被引：0
|
作者：
Ulanova, M [1 ]
Puttagunta, L [1 ]
Marcet-Palacios, M [1 ]
Schreiber, AD [1 ]
Befus, AD [1 ]
机构：
[1] Univ Alberta, Edmonton, AB, Canada
来源：
IMMUNOLOGY 2004: CYTOKINE NETWORK, REGULATORY CELLS, SIGNALING, AND APOPTOSIS | 2004年
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D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We found expression of the tyrosine kinase Syk in human and rodent lung epithelium. Stimulation of bronchial epithelial cells (EC) via beta1 integrin results in rapid cellular redistribution of Syk and beta1 integrin, their co-localization in focal adhesions and Syk phosphorylation on tyrosine. This stimulation increases the expression of inducible nitric oxide synthase (iNOS) and the release of nitric oxide (NO), down-regulated by the Syk inhibitor, piceatannol. Thus, Syk is involved in outside-in signaling initiated by engagement of beta1 integrins in airway EC. Syk-dependent signaling pathways may regulate EC functions, in particular, production of NO.
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页码：401 / 405
页数：5
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