Lynch Syndrome-Associated Colorectal Cancer

被引：158
|
作者：
Sinicrope, Frank A. [1 ,2 ,3 ]
机构：
[1] Mayo Clin, Div Oncol, Rochester, MN 55905 USA
[2] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
[3] Mayo Comprehens Canc Ctr, Rochester, MN 55905 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 08期
关键词：
MISMATCH-REPAIR DEFICIENCY; SUSCEPTIBILITY GENE-MUTATIONS; MICROSATELLITE INSTABILITY; COLON-CANCER; BRAF MUTATION; GERMLINE; MANAGEMENT; MLH1; MSH2; FLUOROURACIL;
D O I：
10.1056/NEJMcp1714533
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 48-year-old man presents with intermittent lower abdominal pain on his right side and reports a weight loss of 4.5 kg (10 lb). He is married and has two healthy teenage children. The physical examination is remarkable for the presence of blood in the stool on digital rectal examination. The hemoglobin level is 11.4 g per deciliter. His mother had a gynecologic cancer at 45 years of age, and his maternal grandfather had colorectal cancer at 63 years of age. Computed tomography of the abdomen and pelvis shows thickening of the cecal wall and pericecal adenopathy. A colonoscopy reveals a polypoid cecal mass, and a biopsy shows poorly differentiated adenocarcinoma. How should this patient be further evaluated and treated?
引用
收藏
页码：764 / 773
页数：10
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