Population-based neuroimaging reveals traces of childbirth in the maternal brain

被引：79
|
作者：
de Lange, Ann-Marie G. [1 ,2 ,3 ,4 ]
Kaufmann, Tobias [2 ,3 ]
van der Meer, Dennis [2 ,3 ,5 ]
Maglanoc, Luigi A. [1 ,2 ,3 ]
Alnaes, Dag [2 ,3 ]
Moberget, Torgeir [1 ,2 ,3 ]
Douaud, Gwenaelle [6 ]
Andreassen, Ole A. [2 ,3 ]
Westlye, Lars T. [1 ,2 ,3 ]
机构：
[1] Univ Oslo, Dept Psychol, N-0373 Oslo, Norway
[2] Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, N-0424 Oslo, Norway
[3] Oslo Univ Hosp, Div Mental Hlth & Addict, N-0424 Oslo, Norway
[4] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England
[5] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, NL-6229 Maastricht, Netherlands
[6] Univ Oxford, Ctr Funct Magnet Resonance Imaging Brain FMRIB, Wellcome Ctr Integrat Neuroimaging, Oxford OX3 9DU, England
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2019年 / 116卷 / 44期
基金：
欧洲研究理事会; 英国医学研究理事会;
关键词：
pregnancy and childbirth; brain imaging; genetics; machine learning; HIPPOCAMPAL NEUROGENESIS; ALZHEIMERS-DISEASE; SEX-DIFFERENCES; PREGNANCY; PLASTICITY; NUMBER; RISK; NEUROPLASTICITY; REPRODUCTION; MOTHERHOOD;
D O I：
10.1073/pnas.1910666116
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Maternal brain adaptations have been found across pregnancy and postpartum, but little is known about the long-term effects of parity on the maternal brain. Using neuroimaging and machine learning, we investigated structural brain characteristics in 12,021 middle-aged women from the UK Biobank, demonstrating that parous women showed less evidence of brain aging compared to their nulliparous peers. The relationship between childbirths and a "younger-looking" brain could not be explained by common genetic variation or relevant confounders. Although prospective longitudinal studies are needed, the results suggest that parity may involve neural changes that could influence women's brain aging later in life.
引用
收藏
页码：22341 / 22346
页数：6
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