SimSCSnTree: a simulator of single-cell DNA sequencing data

被引：3

作者：

Mallory, Xian Fan ^{[1
]}

Nakhleh, Luay ^{[2
]}

机构：

[1] Florida State Univ, Dept Comp Sci, Tallahassee, FL 32306 USA

[2] Rice Univ, Dept Comp Sci, Houston, TX 77025 USA

来源：

BIOINFORMATICS | 2022年 / 38卷 / 10期

基金：

美国国家科学基金会;

关键词：

EVOLUTION;

D O I：

10.1093/bioinformatics/btac169

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A Summary: We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by the simulator can be used to benchmark tools for single-cell genomic analyses, particularly in cancer where SNVs and CNAs are ubiquitous.

引用

页码：2912 / 2914

页数：3

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