The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

被引：10
|
作者：
Chang, Kang [1 ]
Chen, Jian-Qin [1 ]
Shi, Yan-Xia [3 ]
Sun, Mei-Jian [2 ]
Li, Peng-Fei [1 ]
Zhao, Zhen-Jiang [2 ]
Zhu, Wei-Ping [1 ]
Li, Hong-Lin [2 ]
Xu, Yu-Fang [1 ]
Li, Bao-Ju [3 ]
Qian, Xu-Hong [1 ]
机构：
[1] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[3] Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 04期
基金：
国家高技术研究发展计划(863计划);
关键词：
Plant activator; Systemic acquired resistance; Salicylic acid; Benzotriazole; Virtual screening; SYSTEMIC ACQUIRED-RESISTANCE; DISEASE RESISTANCE; 1,2,3-THIADIAZOLE DERIVATIVES; HYBRID APPROACH; BENZOTHIADIAZOLE; SIGNAL; ARABIDOPSIS; INHIBITORS; INDUCERS; TIADINIL;
D O I：
10.1016/j.cclet.2017.02.004
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1'-position and 5'-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：919 / 926
页数：8
相关论文
共 50 条
  • [1] The discovery of new scaffold of plant activators:From salicylic acid to benzotriazole
    Kang Chang
    Jian-Qin Chen
    Yan-Xia Shi
    Mei-Jian Sun
    Peng-Fei Li
    Zhen-Jiang Zhao
    Wei-Ping Zhu
    Hong-Lin Li
    Yu-Fang Xu
    Bao-Ju Li
    Xu-Hong Qian
    ChineseChemicalLetters, 2017, 28 (04) : 919 - 926
  • [2] The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone
    Chang, Kang
    Shi, Yanxia
    Chen, Jianqin
    He, Zenghui
    Xu, Zheng
    Zhao, Zhenjiang
    Zhu, Weiping
    Li, Honglin
    Xu, Yufang
    Li, Baoju
    Qian, Xuhong
    MEDCHEMCOMM, 2016, 7 (09) : 1849 - 1857
  • [3] The Past, Present, and Future of Plant Activators Targeting the Salicylic Acid Signaling Pathway
    Naz, Misbah
    Zhang, Dongqin
    Liao, Kangcen
    Chen, Xulong
    Ahmed, Nazeer
    Wang, Delu
    Zhou, Jingjiang
    Chen, Zhuo
    GENES, 2024, 15 (09)
  • [4] Imprimatins A and B Novel plant activators targeting salicylic acid metabolism in Arabidopsis thaliana
    Noutoshi, Yoshiteru
    Okazaki, Masateru
    Shirasu, Ken
    PLANT SIGNALING & BEHAVIOR, 2012, 7 (12) : 1715 - 1717
  • [5] The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
    Bonn, Peter
    Brink, D. Mikael
    Fagerhag, Jonas
    Jurva, Ulrik
    Robb, Graeme R.
    Schnecke, Volker
    Henriksson, Anette Svensson
    Waring, Michael J.
    Westerlund, Christer
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7302 - 7305
  • [6] 3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators
    Shi, Qinjie
    Shi, Yanxia
    Chang, Kang
    Chen, Jianqin
    Zhao, Zhenjiang
    Zhu, Weiping
    Xu, Yufang
    Li, BaoJu
    Qian, Xuhong
    RSC ADVANCES, 2019, 9 (62) : 36204 - 36207
  • [7] Discovery and Functional Analysis of a Salicylic Acid Hydroxylase from Aspergillus niger
    Lubbers, Ronnie J. M.
    Dilokpimol, Adiphol
    Visser, Jaap
    Hilden, Kristiina S.
    Makela, Miia R.
    de Vries, Ronald P.
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2021, 87 (06) : 1 - 14
  • [8] Discovery of benzotriazole and novel plant metabolites in Arabidopsis and food crops
    LeFevre, Gregory
    Lipsky, Alicia
    Sattely, Elizabeth
    Higgins, Christopher
    Hyland, Katherine
    Luthy, Richard
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [9] New progress in plant disease resistance induced by salicylic acid.
    Shen, WB
    Xu, LL
    Ye, MB
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 1999, 26 (03) : 237 - 240
  • [10] Salicylic acid to decrease plant stress
    Abdul Basit Wani
    Hemlata Chadar
    Abdul Haleem Wani
    Simranjeet Singh
    Niraj Upadhyay
    Environmental Chemistry Letters, 2017, 15 : 101 - 123
12345