EFFICACY AND SAFETY OF PENTAVALENT HUMAN-BOVINE REASSORTANT ROTAVIRUS VACCINE WHEN ADMINISTERED WITH GREATER THAN 10 WEEKS BETWEEN DOSES

被引：13
|
作者：
Goveia, Michelle G. [1 ]
Suprun, Leora [1 ]
Itzler, Robbin F. [1 ]
McFetridge, Richard [1 ]
Dallas, Michael J. [1 ]
Kuter, Barbara J. [1 ]
机构：
[1] Merck & Co Inc, West Point, PA 19486 USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2010年 / 29卷 / 03期
关键词：
rotavirus; RotaTeq; pentavalent rotavirus vaccine; dosing window;
D O I：
10.1097/INF.0b013e3181be6257
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The pentavalent human-bovine reassortant rotavirus vaccine is indicated as a 3-dose series with first dose administered orally at 6 to 12 weeks with subsequent doses at 4 to 10 week intervals. In pre-licensure phase III trials, the majority followed this schedule, but there were 2956 instances where infants received a dose of pentavalent human-bovine reassortant rotavirus vaccine/placebo >10 weeks after the previous dose. Among this subset, the efficacy against any severity of disease, the reduction in utilization of healthcare resources and the safety profile after vaccination were comparable with overall results.
引用
收藏
页码：263 / 265
页数：3
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