Dopamine D2 receptor gene Ser311Cys variant and schizophrenia:: Association study and meta-analysis

被引：53

作者：

Jönsson, EG ^{[1
]}

Sillén, A ^{[1
]}

Vares, M ^{[1
]}

Ekholm, B ^{[1
]}

Terenius, L ^{[1
]}

Sedvall, GC ^{[1
]}

机构：

[1] Karolinska Hosp & Inst, Dept Clin Neurosci, HUBIN Project, Stockholm, Sweden

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2003年 / 119B卷 / 01期

关键词：

genetics; dopamine D-2 receptor gene locus (DRD2); dopamine receptors;

D O I：

10.1002/ajmg.b.20004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An association has been reported between a dopamine D-2 receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, chi(2) = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93,95% confidence interval (95% Cl) 1.61-15.12). The association was detected only in men. The results were supported by a meta-analysis of all published case-control studies comprising a total of 9,152 subjects (chi(2) = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16-1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia. (C) 2003 Wiley-Liss, Inc.

引用

页码：28 / 34

页数：7

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