Synthesis and biological activities of sulfonated polysaccharides having pentofuransidic structures

被引：0
|
作者：
Kang, B. W. [1 ]
Yoshida, T. [2 ]
Lee, J. B. [3 ]
Jeon, S. J. [4 ]
Choi, H. D. [1 ]
机构：
[1] Dong Eui Univ, Dept Chem, Pusan 614714, South Korea
[2] Kitami Inst Technol, Dept Appl Environm Chem, Kitami, Hokkaido 0908507, Japan
[3] Dong Eui Univ, Dept Chem Engn, Busan 614714, South Korea
[4] Dong Eui Univ, Dept Biotechnol & Bioengn, Busan 614714, South Korea
来源：
ASBM7: ADVANCED BIOMATERIALS VII | 2007年 / 342-343卷
关键词：
sulfonated polysaccharide; sulfonation; pentofuranan; anti-HIV;
D O I：
10.4028/www.scientific.net/KEM.342-343.721
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In order to elucidate the relationship between the structure and biological activity such as anti-HIV and blood anticoagulant activity, sulfonated polysaccharides and amino-polysaccharides having pentofuranosidic structures were synthesized. These sulforiated polysaccharides had potent anti-HIV activity in spite of low molecular weights, and which was dependent on the degree of sulfonation. For the blood anticoagulant activity, the conformation of polymer backbone and sulfamide group plays an important role on the interactions with the blood anticoagulant factor.
引用
收藏
页码：721 / +
页数：2
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