Experimental cutaneous sporotrichosis: in vivo evaluation of itraconazole and terbinafine

被引:0
|
作者
Antunes, Tatiana de Avila
Nobre, Marcia de Oliveira [1 ]
de Faria, Renata Osorio [2 ]
Mano Meinerz, Ana Raquel [3 ]
Martins, Anelise Afonso [2 ]
Cleff, Marlete Brum [4 ]
Fernandes, Cristina Gevehr [5 ]
Araujo Meireles, Mario Carlos [4 ]
机构
[1] Univ Fed Pelotas, Fac Vet, Dept Clin Vet, Pelotas, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[3] Univ Fed Pelotas, Fac Vet, Setor Micol, Lab Doencas Infecciosas, Pelotas, RS, Brazil
[4] Univ Fed Pelotas, Fac Vet, Dept Vet Prevent, Pelotas, RS, Brazil
[5] Univ Fed Pelotas, Fac Vet, Dept Anat Patol, Pelotas, RS, Brazil
关键词
Sporotrichosis; Sporothrix schenckii; Terbinafine; Itraconazole; SPOROTHRIX-SCHENCKII; ANTIFUNGAL AGENTS;
D O I
暂无
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The aim Of this Study was to evaluate the in vivo activity of itraconazole and terbinafine for treating experimental cutaneous sporotrichosis. Eighty Wistar rats were used, divided into four groups (TERB20, TERB30, ITRA and CONT). They were inoculated in the left plantar pad with 0.2 ml of solution containing 2x10(3) cell/ml of Sporothrix schenckii and treated with terbinafine (20 and 30 mg/kg), itraconazole (10 mg/kg) or placebo for 13 weeks. The lesions at the inoculation site were evaluated and measured weekly, along with their dissemination. Mycological and histopathological analyses were performed subsequently. The results showed that the animals in the ITRA group differed statistically in all parameters evaluated, in relation to CONT. For terbinafine, there were no statistical differences between the treated and control groups. it could be confirmed that itraconazole presented good activity for treating sporotrichosis, while terbinafine was ineffective for Us disease at the doses used. However, more studies on the latter antifungal agent are needed.
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收藏
页码:706 / 710
页数:5
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