Pathology and physiology of acid-sensitive ion channels in the digestive system (Review)

被引：9

作者：

Zhang, Li ^{[1
]}

Zheng, Liming ^{[1
]}

Yang, Xingyue ^{[1
]}

Yao, Shun ^{[1
]}

Wang, Hui ^{[1
]}

An, Jiaxing ^{[1
]}

Jin, Hai ^{[1
]}

Wen, Guorong ^{[1
]}

Tuo, Biguang ^{[1
,2
]}

机构：

[1] Zunyi Med Univ, Dept Gastroenterol, Affiliated Hosp, Zunyi 563003, Guizhou, Peoples R China

[2] Zunyi Med Univ, Dept Gastroenterol, Affiliated Hosp, 149 dalian Rd, Zunyi 563003, Guizhou, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2022年 / 50卷 / 01期

关键词：

acid-sensitive ion channels; acidic microenvironment; acidosis; digestive system; digestive system diseases; EPITHELIAL-MESENCHYMAL TRANSITION; FACTOR NFATC2 CONTROLS; SENSORY NEURONS; COLONIC HYPERSENSITIVITY; EXTRACELLULAR ACIDOSIS; SENSING ION-CHANNEL-2; MOLECULAR-CLONING; RETINAL FUNCTION; SODIUM-CHANNELS; MELANOMA-CELLS;

D O I：

10.3892/ijmm.2022.5150

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As a major proton-gated cation channel, acid-sensitive ion channels (ASICs) can perceive large extracellular pH changes. ASICs play an important role in the occurrence and development of diseases of various organs and tissues including in the heart, brain, and gastrointestinal tract, as well as in tumor proliferation, invasion, and metastasis in acidosis and regulation of an acidic microenvironment. The permeability of ASICs to sodium and calcium ions is the basis of their physiological and pathological roles in the body. This review summarizes the physiological and pathological mechanisms of ASICs in digestive system diseases, which plays an important role in the early diagnosis, treatment, and prognosis of digestive system diseases related to ASIC expression.

引用

页数：12

共 50 条

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[2] Recent Advances in Acid-sensitive Ion Channels in Central Nervous System Diseases
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[8] Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system
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[9] The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies
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[10] The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies
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