Serum levels of vascular endothelial growth factor A increase during alcohol withdrawal

被引：15
|
作者：
Heberlein, Annemarie [1 ,2 ]
Muschler, Marc [1 ]
Lenz, Bernd [2 ]
Frieling, Helge [1 ,2 ]
Buechl, Christa [2 ]
Groeschl, Michael [3 ]
Riera, Rafael
Kornhuber, Johannes [2 ]
Bleich, Stefan [1 ,2 ]
Hillemacher, Thomas [1 ,2 ]
机构：
[1] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Addict Res Ctr, D-30625 Hannover, Germany
[2] Univ Hosp Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
[3] Univ Hosp Erlangen, Dept Pediat, Erlangen, Germany
来源：
ADDICTION BIOLOGY | 2010年 / 15卷 / 03期
关键词：
Alcohol; dependence; VEGF-A; withdrawal; withdrawal severity; EXPRESSION;
D O I：
10.1111/j.1369-1600.2010.00215.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vascular endothelial growth factor A (VEGF-A) is a key regulator of angiogenesis. This study investigated VEGF-A serum levels during alcohol withdrawal (days 1, 7 and 14, 76 male patients, 38 healthy controls). Patients showed significantly higher VEGF-A serum levels (t = 2.620, P = 0.010), which increased significantly during withdrawal (F = 4.484, P = 0.014, mean difference = -36.835, P = 0.037). The increase of VEGF-A serum levels was significantly associated with initial breath alcohol concentration and the sumscore of the severity scale of alcohol dependence (SESA questionnaire, F = 5.252, P = 0.008). Increase of VEGF-A serum levels is closely associated to alcohol intoxication and severity of alcohol dependence.
引用
收藏
页码：362 / 364
页数：3
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