Label-free oligonucleotide biosensor based on dual-peak long period fiber grating

被引：2

作者：

Chen, Xianfeng ^{[1
]}

Liu, Chen ^{[1
]}

Cardoso, Marcos R. ^{[2
]}

Mendonca, Cleber R. ^{[2
]}

Nagel, David A. ^{[3
]}

Hine, Anna V. ^{[3
]}

Zhang, Lin ^{[4
]}

机构：

[1] Bangor Univ, Sch Elect Engn, Bangor, Gwynedd, Wales

[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-05508 Sao Paulo, Brazil

[3] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

[4] Aston Univ, Aston Inst Photon Technol, Birmingham B4 7ET, W Midlands, England

来源：

OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS XVI | 2016年 / 9702卷

关键词：

Optical fiber biosensor; Long period grating; Label-free; Oligonucleotide; DNA; EDC-mediated reaction;

D O I：

10.1117/12.2207869

中图分类号：

TP7 [遥感技术];

学科分类号：

081102 ; 0816 ; 081602 ; 083002 ; 1404 ;

摘要：

We report the simplification and development of biofunctionalization methodology based on one-step 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated reaction. The dual-peak long period grating (dLPG) has been demonstrated its inherent ultrahigh sensitivity to refractive index (RI), achieving 50-fold improvement in RI sensitivity over a standard LPG sensor used in low RI range. With the simple and efficient immobilization of unmodified oligonucleotides on sensor surface, dLPG-based biosensor has been used to monitor the hybridization of complementary oligonucleotides showing a detectable oligonucleotide concentration of 4 nM with the advantages of label-free, real-time, and ultrahigh sensitivity.

引用

页数：6

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