Regio- and Stereoselective Synthesis of Benzo--sultams by Palladium-Catalyzed Hydrocarbonation of Alkynes

被引：14

作者：

Debnath, Sudarshan ^{[1
]}

Mondal, Shovan ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 05期

关键词：

benzosultams; hydrocarbonation; regioselectivity; DFT study; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; BENZOSULTAMS; CYCLOOXYGENASE-2; DERIVATIVES; CYCLIZATION; INHIBITORS; ANTITUMOR; ALKENES;

D O I：

10.1055/s-0035-1561288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of benzo--sultams [(4Z)-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.

引用

页码：710 / 722

页数：13

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