Regio- and Stereoselective Synthesis of Benzo--sultams by Palladium-Catalyzed Hydrocarbonation of Alkynes

被引：12
|
作者：
Debnath, Sudarshan [1 ]
Mondal, Shovan [1 ]
机构：
[1] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 05期
关键词：
benzosultams; hydrocarbonation; regioselectivity; DFT study; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; BENZOSULTAMS; CYCLOOXYGENASE-2; DERIVATIVES; CYCLIZATION; INHIBITORS; ANTITUMOR; ALKENES;
D O I：
10.1055/s-0035-1561288
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of benzo--sultams [(4Z)-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.
引用
收藏
页码：710 / 722
页数：13
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