Six New Steroidal Saponins from Helleborus thibetanus

被引：12

作者：

Zhang, Hui ^{[1
]}

Su, Yan-Fang ^{[1
]}

Yang, Feng-Ying ^{[1
]}

Zhao, Ze-Qing ^{[1
]}

Gao, Xiu-Mei ^{[2
]}

机构：

[1] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 12期

关键词：

SPIROSTANOL GLYCOSIDES; RHIZOMES; ORIENTALIS; CAUCASICUS;

D O I：

10.1002/hlca.201400080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six steroidal saponins, including five spirostanol glycosides, 1-5, and one furostanol glycoside 1-sulfonate, 6, previously unknown in nature, together with three known compounds, 7-9, were isolated from dried roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive 1D- and 2D-NMR experiments, along with IR and HR-ESI-MS data, as well as the results of acid hydrolysis. Compounds 1-5 possessed a C(25)=C(27) bond and were glycosylated at HO=C(1), which was unusual in steroidal saponins.

引用

页码：1652 / 1665

页数：14

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