c-Fos positive nucleus reveals that contextual specificity of latent inhibition is dependent of insular cortex

被引:7
|
作者
Quintero, Esperanza [1 ]
Pedro Vargas, Juan [1 ]
Diaz, Estrella [1 ]
Dolores Escarabajal, Maria [2 ]
Carrasco, Manuel [3 ]
Carlos Lopez, Juan [1 ]
机构
[1] Univ Seville, Dept Psicol Expt, Lab Conducta Anim & Neurociencia, Seville 41018, Spain
[2] Univ Jaen, Dept Psicol, Jaen, Spain
[3] Univ Cadiz, Area Fisiol, Dept Biomed Biotecnol & Salud Publ, Cadiz, Spain
关键词
Agranular insular cortex; c-Fos expression; Contextual specificity; Granular insular cortex; Latent inhibition; CONDITIONED TASTE-AVERSION; RECOGNITION MEMORY; EXPRESSION; LESIONS; RAT; AMYGDALA; BRAIN; RETRIEVAL; INDUCTION; LICL;
D O I
10.1016/j.brainresbull.2014.08.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study analyzed the functional activity of granular and agranular insular cortices in contextual specificity of latent inhibition using a conditioned taste aversion paradigm. c-Fos immunolabeling was examined in insular cortex in preexposed and no preexposed groups under similar and different context conditions. Result showed that the exposition to a novel taste increased c-fos activity in insular cortex. However, a context shift caused an increase in immunolabeling in animals preexposed to saccharine. These results suggest insular cortex is part of a complex system to evaluate taste-response, and it may read the meaning of taste stimuli depending on the context. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:74 / 79
页数:6
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