Model predicting the ypN0 status after good response to chemoradiotherapy in rectal cancer

被引：3
|
作者：
Dumont, E. [1 ]
Dartigues, P. [2 ]
Delga, B. [1 ]
Thibaudeau, E. [1 ]
Benhaim, L. [3 ]
Campion, L. [4 ]
Mosnier, J. F. [5 ]
Raimbourg, J. [6 ]
Kerdraon, O. [7 ]
Goere, D. [3 ]
机构：
[1] West Oncol Inst, Dept Digest Oncol Surg, St Herblain, France
[2] Gustave Roussy Canc Campus, Dept Pathol, Villejuif, France
[3] Gustave Roussy Canc Campus, Dept Digest Oncol Surg, Villejuif, France
[4] West Oncol Inst, Dept Stat, St Herblain, France
[5] Univ Hosp, Dept Pathol, Nantes, France
[6] West Oncol Inst, Dept Oncol, St Herblain, France
[7] West Oncol Inst, Dept Pathol, St Herblain, France
来源：
AMERICAN JOURNAL OF SURGERY | 2018年 / 216卷 / 03期
关键词：
Rectal cancer; Chemoradiotherapy; Nodal staging; Lymph node; Chemoradiotherapy T status; Good response; PATHOLOGICAL COMPLETE RESPONSE; LYMPH-NODE METASTASES; PREOPERATIVE CHEMORADIATION; NEOADJUVANT CHEMORADIOTHERAPY; RANDOMIZED-TRIAL; LOCAL EXCISION; METAANALYSIS; CARCINOMA; THERAPY; OXALIPLATIN;
D O I：
10.1016/j.amjsurg.2018.03.025
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: The purpose of this study was to identify the predictive factors for ypN0 status in tumors with good pathologic response to chemoradiotherapy (CRT). Methods: A retrospective chart review was conducted on patients at two tertiary cancer center who underwent rectal resection after good response to CRT between 2000 and 2013. Results: No preoperative treatment (oxaliplatin use, radiotherapy boost of 5,4 Gy, delay CRT-surgery) impacted on the ypN status. In the multivariate analysis, only a ypT<3 (HR 7.5 [2,9-19.5]) was significant and no lymphovascular invasion (HR 8,9 [1.6-49.8]) was limited to significance.The best model predicting the ypN0 status used only the ypT status<3. The major part (92.2%) of patients with ypT0-2 tumors had no LN invasion. Conclusion: The risk of lymph node involvement metastases was only 7.8% for the patients with an ypT0-2 status. A fullthickness transanal resection coud be the futur treatment of these patients. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：438 / 443
页数：6
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