Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

被引：22
|
作者：
Khan, S. A. [1 ]
Ahmad, W. [1 ]
Munawar, K. S. [1 ]
Kanwal, Sadia [2 ]
机构：
[1] Univ Management & Technol, Dept Chem, Lahore 54000, Pakistan
[2] Univ Agr Faisalabad, Dept Biochem, Faisalabad 38000, Pakistan
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 80卷 / 03期
关键词：
Diphenyldithiocarbamate (DPDTC); spectroscopic studies; antioxidant; antibacterial; antifungal activities; CHARGE-TRANSFER PHOTOCHEMISTRY; DOPED ZNO NANOPARTICLES; OXIDE NANOPARTICLES; ABUTILON-INDICUM; METAL-COMPLEXES; GREEN SYNTHESIS; ANTIBACTERIAL; ANTIOXIDANT; ANTIFUNGAL;
D O I：
10.4172/pharmaceutical-sciences.1000381
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ni(II), Cu(II) and Zn(II) complexes of diphenyldithiocarbamate have been synthesized with the aim of developing antioxidants, potential antibacterial and antifungal agents. Synthesized metal complexes were characterized by magnetic susceptibility, elemental analysis; conductivity measurements, mass spectra, infrared, ultra violet/visible and nuclear magnetic resonance verified the chemical composition of products. Magnetic susceptibility and spectroscopic studies suggested the predicted geometry of the diphenyldithiocarbamate complexes as octahedral geometry of Ni(II) complex distortion square-planer geometry distorted towards tetrahedral for Cu(II) and Zn(II) complexes. Synthesized metal complexes exhibited remarkable antioxidant potential as compared to standard. Zn(II) complex of diphenyldithiocarbamate exhibited IC50 of 31.45 +/- 0.31 mu M while the standard, butylated hydroxytoluene exhibited IC50 of 44.67 +/- 0.45 mu M antioxidant activity. Synthesized metal complexes showed very good antibacterial and antifungal potential against Rhodococcuss, Actinomyces viscosus, Bacillus subtilis, Escherichia coli and the fungi, Aspergillus niger, Aspergillus flavus, Candida and Acetomyceta. It's concluded that synthesized metal complexes showed better antioxidant, antibacterial and antifungal potential as compared to diphenyldithiocarbamate as well as the standard and might turn out to be a valuable treatment of numerous kinds of diseases.
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收藏
页码：480 / 488
页数：9
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