Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling

被引:36
|
作者
Zich, Judith [1 ]
Hardwick, Kevin G. [1 ]
机构
[1] Univ Edinburgh, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland
关键词
ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; KINETOCHORE-MICROTUBULE ATTACHMENT; AURORA-B KINASE; MITOTIC CHECKPOINT; ASSEMBLY CHECKPOINT; CHROMOSOME SEGREGATION; CRYSTAL-STRUCTURE; MAD2; ACTIVATION; BUB1; PROVIDES; CENP-E;
D O I
10.1016/j.tibs.2009.09.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Due to the highly orchestrated stages of mitosis, cells segregate their chromosomes with incredibly high fidelity. One of the principal 'conductors' is the spindle checkpoint, which regulates mitotic progression. Specifically, it delays anaphase onset until all chromosomes are attached in a bi-oriented fashion to spindle microtubules. This delay stems from inhibition of Cdc20, an activator of an E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C). Several recent advances in our mechanistic understanding of this important cell cycle control have been made. Although still poorly understood, signalling roles for checkpoint kinases and their opposing phosphatases continue to be uncovered, and the key substrates gradually identified.
引用
收藏
页码:18 / 27
页数:10
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