A new approach to the rapid parallel development of four neurokinin antagonists. Part 3. Assembly of neurokinin antagonists

被引：16

作者：

Parker, JS ^{[1
]}

Bowden, SA ^{[1
]}

Firkin, CR ^{[1
]}

Moseley, JD ^{[1
]}

Murray, PM ^{[1
]}

Welham, MJ ^{[1
]}

Wisedale, R ^{[1
]}

Young, MJ ^{[1
]}

Moss, WO ^{[1
]}

机构：

[1] AstraZeneca, Proc Res & Dev, Avlon Works, Bristol BS10 7ZE, Avon, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 01期

关键词：

D O I：

10.1021/op020066+

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four neurokinin antagonists were assembled using a rapid parallel development approach. Research Department processes were scaled up if process safety and robustness were not compromised. Using this approach, 1 kg of each compound was rapidly delivered for clinical trials.

引用

页码：67 / 73

页数：7

共 34 条

[1] A new approach to rapid parallel development for four neurokinin antagonists. Part 1.
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[2] A new approach to rapid parallel development of four neurokinin antagonists. Part 2. Synthesis of ZD6021 cyano acid
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[3] A new approach to the rapid parallel development of four neurokinin antagonists. Part 5. Preparation of ZM374979 cyanoacid and selective crystallisation of ZM374979 atropisomers
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