Interactions of the orexin/hypocretin neurones and the histaminergic system

被引：26
|
作者：
Sundvik, M. [1 ]
Panula, P. [1 ]
机构：
[1] Univ Helsinki, Inst Biomed, Anat & Neurosci Ctr, FIN-00290 Helsinki, Finland
来源：
ACTA PHYSIOLOGICA | 2015年 / 213卷 / 02期
基金：
芬兰科学院;
关键词：
autoimmune; histamine; hypocretin; orexin; mouse; narcolepsy; zebrafish; CEREBROSPINAL-FLUID HISTAMINE; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; OREXIN-NULL MICE; HISTIDINE-DECARBOXYLASE; H-3; RECEPTOR; BRAIN HISTAMINE; HYPOCRETIN NEURONS; TUBEROMAMMILLARY NUCLEUS; NARCOLEPSY-CATAPLEXY;
D O I：
10.1111/apha.12432
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Histaminergic and orexin/hypocretin systems are components in the brain wake-promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.
引用
收藏
页码：321 / 333
页数：13
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