Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

被引：68
|
作者：
Zhao, Weiwei [1 ]
Wang, Hua [2 ]
Wang, Haimang [1 ]
Han, Ying [1 ]
Zheng, Zhibo [3 ]
Liu, Xudong [4 ]
Feng, Bin [5 ]
Zhang, Hongyu [1 ]
机构：
[1] Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
[3] Chinese Acad Med Sci, Dept Int Med Serv, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
[4] Chinese Acad Med Sci, Med Sci Res Ctr, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
[5] Chinese Acad Med Sci, Dept Orthopaed Surg, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
来源：
NANOSCALE | 2021年 / 13卷 / 13期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
35;
D O I：
10.1039/d0nr08887k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and beta-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.
引用
收藏
页码：6394 / 6399
页数：6
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