Development of Non-Polyamine based Polyamine Transport Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma

被引：0
|
作者：
Moots, Holly [1 ]
Phanstiel, Otto [1 ]
机构：
[1] Univ Cent Florida, Med Educ, Orlando, FL 32816 USA
来源：
FASEB JOURNAL | 2019年 / 33卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
652.13
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Sustained Polyamine Depletion for the Treatment of Pancreatic Ductal Adenocarcinoma
    Dobrovolskaite, Aiste
    Altomare, Deborah
    Phanstiel, Otto
    FASEB JOURNAL, 2019, 33
  • [2] An overview of polyamine metabolism in pancreatic ductal adenocarcinoma
    Phanstiel, Otto
    INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (10) : 1968 - 1976
  • [3] Development of Polyamine Lassos as Polyamine Transport Inhibitors
    Dobrovolskaite, Aiste
    Gardner, Richard Andrew
    Delcros, Jean-Guy
    Phanstiel, Otto
    ACS MEDICINAL CHEMISTRY LETTERS, 2022, 13 (02): : 319 - 326
  • [4] Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis.
    Lee, Min-Sik
    Naqvi, Insia
    Dennis, Courtney
    Dailey, Lucas
    Lorzadeh, Alireza
    Zaytouni, Tamara
    Adler, Ashley
    Hitchcock, Daniel S.
    Lin, Lin
    Jadhav, Unmesh
    Clish, Clary B.
    Kalaany, Nada Y.
    CANCER RESEARCH, 2021, 81 (22) : 21 - 21
  • [5] The discovery of indolone GW5074 during a comprehensive search for non-polyamine-based polyamine transport inhibitors
    Dobrovolskaite, Aiste
    Madan, Meenu
    Pandey, Veethika
    Altomare, Deborah A.
    Phanstiel, Otto
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021, 138
  • [6] SELECTIVE INHIBITORS OF TRANSMEMBRANE POLYAMINE TRANSPORT
    AZIZ, SM
    TOFIQ, SF
    OLSON, JW
    GILLESPIE, MN
    FASEB JOURNAL, 1994, 8 (04): : A12 - A12
  • [7] Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma
    Tedeschi, Antonio
    Schaaf, Otmar
    Gmachl, Michael
    Herdeis, Lorenz
    Rocchetti, Francesca
    Popow, Johannes
    Schischlik, Fiorella
    Gerlach, Daniel
    Lipp, Jesse
    Broker, Joachim
    Mantoulidis, Andreas
    Smethurst, Chris
    Kessler, Dirk
    Boettcher, Jark
    Wunberg, Tobias
    Santoro, Valeria
    Waterson, Alex
    Phan, Jason
    Little, Andrew
    Abbott, Jason
    Sun, Qi
    Fesik, Stephen
    Mcconnell, Darryl
    Pearson, Mark A.
    Kraut, Norbert
    Rudolph, Dorothea
    CANCER RESEARCH, 2024, 84 (02)
  • [8] Emerging kinase inhibitors for the treatment of pancreatic ductal adenocarcinoma
    Rudloff, Udo
    EXPERT OPINION ON EMERGING DRUGS, 2022, 27 (03) : 345 - 368
  • [9] A phase 1 safety study of SBP-101, a polyamine metabolic inhibitor, for pancreatic ductal adenocarcinoma (PDA).
    Tebbutt, Niall C.
    Kotasek, Dusan
    Borad, Mitesh J.
    Borazanci, Erkut Hasan
    Smith, Sheri Lynn
    Shah, Ajit K.
    Walker, Michael J.
    Cullen, Michael T.
    Gagnon, Suzanne
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [10] Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model
    von Kalm, Laurence
    Wang, Minpei
    Phanstiel, Otto
    FASEB JOURNAL, 2019, 33
12345