Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome

被引:45
|
作者
Ota, Hiroyo [1 ]
Fujita, Yukio [1 ]
Yamauchi, Motoo [1 ]
Muro, Shigeo [1 ]
Kimura, Hiroshi [2 ]
Takasawa, Shin [3 ]
机构
[1] Nara Med Univ, Dept Internal Med 2, Kashihara, Nara 6348522, Japan
[2] Nippon Med Sch Grad Sch Med, Dept Adv Med Pulm Circulat & Resp Failure Donat C, Bunkyo Ku, Tokyo 1138602, Japan
[3] Nara Med Univ, Dept Biochem, Kashihara, Nara 6348521, Japan
关键词
type; 2; diabetes; intermittent hypoxia; glucose-induced insulin secretion; pancreatic beta cell proliferation; hepatokines; adipokines; myokines; sleep apnea syndrome; POSITIVE AIRWAY PRESSURE; CYCLIC ADP-RIBOSE; ADIPOSE-TISSUE INFLAMMATION; BETA-CELL REPLICATION; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; SELENOPROTEIN P; UP-REGULATION; CONTROLLED-TRIAL; SIGNALING ROLE;
D O I
10.3390/ijms20194756
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sleep apnea syndrome (SAS) is a very common disease involving intermittent hypoxia (IH), recurrent symptoms of deoxygenation during sleep, strong daytime sleepiness, and significant loss of quality of life. A number of epidemiological researches have shown that SAS is an important risk factor for insulin resistance and type 2 diabetes mellitus (DM), which is associated with SAS regardless of age, gender, or body habitus. IH, hallmark of SAS, plays an important role in the pathogenesis of SAS and experimental studies with animal and cellular models indicate that IH leads to attenuation of glucose-induced insulin secretion from pancreatic beta cells and to enhancement of insulin resistance in peripheral tissues and cells, such as liver (hepatocytes), adipose tissue (adipocytes), and skeletal muscles (myocytes). In this review, we focus on IH-induced dysfunction in glucose metabolism and its underlying molecular mechanisms in several cells and tissues related to glucose homeostasis.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Relationship Between Type 2 Diabetes Mellitus and Obstructive Sleep Apnea Syndrome
    Todea, Doina Adina
    Postolache, Paraschiva
    Coman, Andreea Codruta
    Rosca, Loredana Elena
    [J]. CHEST, 2014, 145 (03)
  • [2] A Specific Type of Diabetes Induced by Intermittent Hypoxia in a Mouse Model of Sleep Apnea
    Polak, Jan
    Shimoda, Larissa A.
    Drager, Luciano F.
    Polotsky, Vsevolod Y.
    Punjabi, Naresh M.
    [J]. DIABETES, 2012, 61 : A484 - A484
  • [3] Relationship between obstructive sleep apnea and type 2 diabetes mellitus
    Abelleira, Romina
    Zamarron, Carlos
    Riveiro, Vanessa
    Casal, Ana
    Toubes, Maria Elena
    Rabade, Carlos
    Ricoy, Jorge
    Lama, Adriana
    Rodriguez-Nunez, Nuria
    Ferreiro, Lucia
    Rodriguez-Ozores, Juan
    Valdes, Luis
    [J]. MEDICINA CLINICA, 2024, 162 (08): : 363 - 369
  • [4] Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome
    Sha-Sha Tang
    Cheng-Hong Liang
    Ya-Lei Liu
    Wei Wei
    Xin-Ru Deng
    Xiao-Yang Shi
    Li-Min Wang
    Li-Jun Zhang
    Hui-Juan Yuan
    [J]. World Journal of Gastroenterology, 2022, (21) : 2320 - 2333
  • [5] Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome
    Tang, Sha-Sha
    Liang, Cheng-Hong
    Liu, Ya-Lei
    Wei, Wei
    Deng, Xin-Ru
    Shi, Xiao-Yang
    Wang, Li-Min
    Zhang, Li-Jun
    Yuan, Hui-Juan
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2022, 28 (21) : 2320 - 2333
  • [6] The relationships between intermittent hypoxia and oxidative stress in patients with sleep apnea syndrome
    Tokunou, Tomotake
    Yoshikawa, Tomoko
    Yoshioka, Yasuko
    Ando, Shin-ichi
    [J]. SLEEP AND BIOLOGICAL RHYTHMS, 2024,
  • [7] The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
    Siwasaranond, Nantaporn
    Nimitphong, Hataikarn
    Manodpitipong, Areesa
    Saetung, Sunee
    Chirakalwasan, Naricha
    Thakkinstian, Ammarin
    Reutrakul, Sirimon
    [J]. JOURNAL OF DIABETES RESEARCH, 2018, 2018
  • [8] Sleep Apnea-Hypopnea Syndrome and Type 2 Diabetes. A Reciprocal Relationship?
    Martinez Ceron, Elisabet
    Casitas Mateos, Raquel
    Garcia-Rio, Francisco
    [J]. ARCHIVOS DE BRONCONEUMOLOGIA, 2015, 51 (03): : 128 - 139
  • [9] Intermittent Hypoxia for Obstructive Sleep Apnea?
    Windsor, Jeremy S.
    Rodway, George W.
    [J]. HIGH ALTITUDE MEDICINE & BIOLOGY, 2014, 15 (04) : 442 - 443
  • [10] Effects of type 2 diabetes on the quality of sleep in patients with sleep apnea syndrome
    Kamgang, J.
    Kuate, C.
    Sobngwi, E.
    Azabji, M.
    Mbanya, J. C.
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 103 : S47 - S47