Divergent synthesis of cytotoxic styryl lactones isolated from Polyalthia crassa. The first total synthesis of crassalactone B

被引：16

作者：

Popsavin, Velimir ^{[1
]}

Benedekovic, Goran ^{[1
]}

Popsavin, Mirjana ^{[1
]}

Kojic, Vesna ^{[2
]}

Bogdanovic, Gordana ^{[2
]}

机构：

[1] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia

[2] Oncol Inst Vojvodina, Sremska Kamenica 21204, Serbia

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 26期

关键词：

LONGIFOLIA VAR.-PENDULA; CLERODANE DITERPENES; MELDRUMS ACID; ALKALOIDS;

D O I：

10.1016/j.tetlet.2010.04.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (+)-crassalactone B (2) and a new syntheses of (+)-crassalactone C(3) has been achieved starting from D-glucose. The natural products 2 and 3 can be selectively accessed by changing the conditions for TBDPS cleavage in the final intermediate 16. The synthesized natural products were evaluated for their cytotoxic activity against a panel of human tumour cell lines. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3426 / 3429

页数：4

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