PROCESS DEVELOPMENT USING QUALITY BY DESIGN PRINCIPLES FOR IMPROVED CAR-T PRODUCTION IN AN AUTOMATED SINGLE USE PERFUSION STIRRED-TANK BIOREACTOR

被引：0
|
作者：
Hood, T. [1 ]
Slingsby, F. [2 ]
Sandner, V. [3 ,4 ]
Bevan, N.
Geis, W. [5 ]
Dianat, N. [3 ]
Nienow, A. [1 ,6 ]
Vicard, Q. [3 ]
Rafiq, Q. A. [1 ]
机构：
[1] UCL, Dept Biochem Engn, London, England
[2] Sartorius Stedim Biotech, Royston, England
[3] Sartorius Stedim France SAS, Aubagne, France
[4] Sartorius Stedim Austria GmbH, Vienna, Austria
[5] Sartorius Stedim Biotech GmbH, Gottingen, Germany
[6] Univ Birmingham, Chem Engn, Birmingham, W Midlands, England
来源：
CYTOTHERAPY | 2022年 / 24卷 / 05期
关键词：
Bioreactor; CAR-T; Perfusion;
D O I：
暂无
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
953
引用
收藏
页码：S184 / S185
页数：2
相关论文
共 15 条
  • [1] OPTIMISING PERFUSION PARAMETERS USING QUALITY BY DESIGN FOR THE INTENSIFIED PRODUCTION OF CAR T CELLS IN A SINGLE-USE AUTOMATED STIRRED-TANK BIOREACTOR
    Springuel, P.
    Hood, T.
    Slingsby, F.
    Bevan, N.
    Geis, W.
    Sandner, V.
    Schmidberger, T.
    Hengst, J.
    Dianat, N.
    Rafiq, Q. A.
    CYTOTHERAPY, 2023, 25 (06) : S202 - S202
  • [2] A NOVEL MANUFACTURING PROCESS FOR CAR-T CELL THERAPIES IN AN AUTOMATED STIRRED-TANK BIOREACTOR
    Costariol, E.
    Rafiq, Q. A.
    CYTOTHERAPY, 2019, 21 (05) : S34 - S35
  • [3] Demonstrating the Manufacture of Human CAR-T Cells in an Automated Stirred-Tank Bioreactor
    Costariol, Elena
    Rotondi, Marco C.
    Amini, Arman
    Hewitt, Christopher J.
    Nienow, Alvin W.
    Heathman, Thomas R. J.
    Rafiq, Qasim A.
    BIOTECHNOLOGY JOURNAL, 2020, 15 (09)
  • [4] A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors
    Hood, Tiffany
    Slingsby, Fern
    Sandner, Viktor
    Geis, Winfried
    Schmidberger, Timo
    Bevan, Nicola
    Vicard, Quentin
    Hengst, Julia
    Springuel, Pierre
    Dianat, Noushin
    Rafiq, Qasim A.
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [5] TUNING CAR-T CELL PHENOTYPE THROUGH ENHANCED BIOPROCESS CONTROL IN AN AUTOMATED STIRRED-TANK BIOREACTOR
    Tomas, H.
    Costa, M. S.
    Costa, C.
    Duarte, N.
    Alves, P.
    Costa, M.
    Serra, M.
    CYTOTHERAPY, 2024, 26 (06) : S20 - S20
  • [6] Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach
    Hood, Tiffany
    Springuel, Pierre
    Slingsby, Fern
    Sandner, Viktor
    Geis, Winfried
    Schmidberger, Timo
    Bevan, Nicola
    Vicard, Quentin
    Hengst, Julia
    Dianat, Noushin
    Rafiq, Qasim A.
    BIOENGINEERING & TRANSLATIONAL MEDICINE, 2025,
  • [7] Optimizing CAR-T process development by utilizing a novel small scale stirred tank bioreactor
    Vicard, Q.
    Nascimento, L.
    Masri, F.
    HUMAN GENE THERAPY, 2019, 30 (11) : A74 - A74
  • [8] PROCESS DEVELOPMENT FOR SCALABLE ALLOGENEIC CAR-T MANUFACTURING IN STIRRED -TANK BIOREACTORS: PERFUSION OPTIMISATION, MULTI -LITRE SCALE-UP AND AUTOMATED HARVESTING
    Springuel, P.
    Hood, T.
    Slingsby, F.
    Bevan, N.
    Frangleton, A.
    Szelwicki, M.
    Schmidberger, T.
    Geis, W.
    Hengst, J.
    Dianat, N.
    Rafiq, Q.
    CYTOTHERAPY, 2024, 26 (06) : S197 - S197
  • [9] Cultivation of E-FL in perfusion mode using Wave® Bioreactor and stirred-tank reactor for parvovirus vaccine production
    Hundt, B.
    Straube, S.
    Schlawin, N.
    Kassner, H.
    Reichl, U.
    CELL TECHNOLOGY FOR CELL PRODUCTS, 2007, : 519 - +
  • [10] High-throughput fermentation process design with single-use stirred-tank bioreactors
    Weuster-Botz, Dirk
    JOURNAL OF BIOTECHNOLOGY, 2008, 136 : S279 - S280
12